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Orthogon Therapeutics Raises an Additional $11M Financing for Its BK Virus Antiviral Drug Program

Business Wire India — Sat, 18 Apr 2026 10:58:55 +0530

Business Wire India

Orthogon Therapeutics today announced the closing of a follow-on $11 million financing, bringing its total capital raised to $36 million. This financing supports the continued advancement of its first-in-class drug against BK polyomavirus. BK virus infections are a major cause of complications in transplant patients, with no approved treatments.

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Electron microscope image of BK virus, showing the VP1 capsid protein that creates an icosahedral shell around the viral genome.

The company is pioneering an oral therapy that addresses the full spectrum of BK infection, from early reactivation through systemic spread and onset of severe disease. By targeting viral proteins previously considered inaccessible to small molecule drugs, Orthogon is advancing a solution where other therapeutic modalities have fallen short.

Orthogon’s lead asset uniquely targets the viral capsid protein (VP1), delivering potent antiviral effect at the site of viral replication. The intracellular activity leads to sustained control of viral infection across BK variants and related human polyomaviruses, particularly in transplant patients, where viral persistence drives disease.

“This is not a conventional antiviral setting. We built this program to meet the realities of transplant care,” said Ali H. Munawar, Ph.D., CEO of Orthogon Therapeutics. “These patients are treated within a narrow balance of immunosuppression, organ function, and high pill burden. We designed around those constraints, arriving at a candidate profile that we’re excited to take into development.”

In parallel, Orthogon has published findings examining hundreds of patient-derived BK virus sequences, showing that the virus carries pre-existing diversity at antibody-binding regions and that it replicates beyond the reach of circulating antibodies. These studies explain the limited clinical benefit observed with neutralizing antibodies, challenges that Orthogon’s drug is designed to overcome.

The program draws on Orthogon’s portfolio of novel small molecules directed at each of the two viral proteins: the VP1 capsid and large T antigen (LTAg), a capability that has eluded the field for decades. The program will be featured at leading transplant and virology meetings in 2026, building on findings presented at the ASN in 2025.

Alongside its core focus on polyomaviruses, Orthogon is advancing programs in additional areas of unmet need in transplant-associated infections.

About BK and polyomaviruses:

BK virus (BKV) is among the most widespread chronic viral infections in humans. A member of the polyomavirus family, BKV establishes a lifelong infection in 80–90% of healthy adults worldwide. Reactivation occurs in the kidneys of nearly half of all solid organ and stem cell transplant recipients, leading to severe complications and graft loss. Other human polyomaviruses, including JC virus and Merkel cell polyomavirus, cause fatal progressive multifocal leukoencephalopathy (PML) and aggressive Merkel cell carcinoma, respectively.

About Orthogon Therapeutics:

Orthogon is a polyomavirus-focused biotech built on a proprietary discovery platform that fuses structure-based drug design with deep biophysical interrogation of viral proteins, unlocking targets long considered undruggable. The company is headquartered in Greater Boston with a research branch in Leuven, Belgium. To learn more visit www.orthogontherapeutics.com

Orthogon Therapeutics LLC is an independent, privately held research & development (R&D) company affiliated with the Pledge Therapeutics discovery engine. More info on www.pledge-tx.com

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How Accurate Are Personal Loan EMI Calculators: A Deep Dive Into Hidden Assumptions

Business Wire India — Sat, 11 Apr 2026 00:49:15 +0530

Business Wire India

Personal loan EMI calculators are widely used by borrowers to estimate monthly repayments before committing to a loan. With digital loans on the rise, these tools have become a standard part of the borrowing process, especially for those exploring quick approvals and simplified processes. While calculators offer clarity, their accuracy depends on the assumptions built into them.

Knowing how accurate these calculators are helps borrowers avoid misplaced confidence and plan more realistically.

What Personal Loan EMI Calculators Are Designed To Do

A personal loan calculator estimates the monthly EMI using three key inputs. Loan amount, interest rate, and tenure.

Based on standard amortisation formulas, the calculator shows an EMI figure and total interest payable. For most borrowers, this provides a useful starting point for affordability assessment.

However, calculators are designed to simplify reality. They are not meant to capture every variable that affects actual repayment.

The Core Assumptions Behind EMI Calculations

Every EMI calculator relies on a set of assumptions that remain invisible to most users.

These assumptions include a

Fixed interest rate,
Uninterrupted repayment
On time EMI deductions.

The calculator also assumes that the loan runs exactly as planned, without restructuring, delays, or changes.

When borrowers use an instant personal loan option, the speed of approval makes it even more important to recognise these assumptions before relying on the numbers shown.

For instance, FIRSTmoney Personal Loan by IDFC FIRST Bank comes with instant disbursal of up to Rs.15 lakh within 10 minutes through a 100% digital application process. However, you should still use EMI calculators carefully to ensure the repayment plan fits comfortably beyond the speed of access.

Where EMI Calculators Are Highly Accurate

EMI calculators are most accurate when the loan structure matches the assumptions closely.

For loans with fixed interest rates, fixed tenure, and no additional charges rolled into the loan, calculator outputs usually align well with actual EMIs. In such cases, the monthly figure shown is a reliable estimate.

As long as repayments happen on schedule and terms remain unchanged, the calculator performs exactly as intended.

Hidden Costs EMI Calculators Do Not Always Include

Many calculators do not account for processing fees, insurance premiums, or documentation charges if these are added to the loan amount. This can slightly increase actual EMIs compared to initial estimates.

Borrowers using a personal loan calculator should always confirm whether fees are deducted upfront or financed, as this affects real repayment figures.

Assumptions Around Interest Rate Stability

EMI calculators usually assume that the interest rate remains constant throughout the loan tenure. This is accurate for fixed rate loans, but not always for floating rate structures.

If the interest rate changes due to policy revisions or benchmark adjustments, EMIs may increase or tenure may extend. Calculators do not simulate these future changes.

Behavioural Assumptions Borrowers Often Ignore

Calculators also assume perfect borrower behaviour. They assume no missed EMIs, no delays, and no changes in income. Salary gaps, unexpected expenses, or account mandate issues can lead to penalties or interest accrual that calculators do not reflect.

This is particularly relevant for borrowers relying on instant personal loan disbursals without building buffers.

How Calculators Handle Prepayments and Foreclosure

Most basic EMI calculators do not factor in prepayments or early closure scenarios. They show repayment assuming the loan runs full term.

If borrowers plan to prepay, actual interest paid may be lower than what the calculator shows. However, this depends on prepayment rules and charges, which calculators do not evaluate.

In this context, you can consider options like FIRSTmoney Personal Loan by IDFC FIRST Bank where foreclosure charges are zero. Hence, you can close loans early without added financial strain.

Why Calculators Still Matter Despite Limitations

Despite these gaps, personal loan EMI calculator remain valuable because they remove guesswork from core loan planning.

They help borrowers compare scenarios, test tenures, and assess whether an EMI fits comfortably within monthly budgets. Even if not perfectly precise, they are far better than relying on assumptions or lender eligibility alone.

Eligibility for digital personal loans like FIRSTmoney by IDFC FIRST Bank typically include a stable monthly income, a CIBIL score of 710 or above, and age between 21 and 60 years old.

Common Misinterpretations to Avoid

Borrowers often treat calculator results as final quotes. This leads to disappointment when actual EMIs differ slightly.

Another mistake is using calculators to justify maximum borrowing rather than comfortable borrowing. Approval eligibility does not equal repayment comfort.

Insights and content strategy for this article were supported by Teamology.

Kesar India Limited Builds Strong Growth Pipeline Worth Over ₹5,100 Crore

Business Wire India — Sat, 11 Apr 2026 00:49:12 +0530

Business Wire India

Key Highlights

Development pipeline of INR 5,100+ crore GDV
~12.24 million sq. ft. developable area
29 projects across residential and mixed-use
3–5 years execution visibility
Additional INR 4,000+ crore GDV under evaluation

Kesar India Limited (“the Company”), a Nagpur-based real estate development company engaged in quality residential, commercial, and mixed‑use projects, announced a significant expansion of its long-term development pipeline through a series of strategic land acquisitions, marking a pivotal shift towards building scale, visibility and sustainability in its growth strategy.

Over the past year, the Company has actively consolidated land parcels to address key industry challenges such as rising land acquisition costs and limited future project visibility. Moving away from a short-term acquisition model, Kesar India has focused on assembling a structured and sustainable development pipeline, offering an estimated 3–5 years of execution visibility.

The Company estimates total project investments exceeding INR 2,000 crore, to be deployed in a phased and disciplined manner aligned with execution milestones.

Pipeline Overview:

~12.24 million sq. ft. of developable area
Estimated Gross Development Value (GDV) exceeding INR 5,100 crore
29 projects across residential, mixed‑use and large‑format developments

This expanded pipeline positions Kesar India among the emerging real estate developers in Central India supported by a scaled, well-diversified and forward-looking project portfolio.

Commenting on the development, Mr. Sachin Gopal Gupta, Managing Director, Kesar India Limited, said, “The strategic acquisitions reflect our intent to build a long-term, scalable platform rather than operate on a project-to-project basis. By strengthening our land bank at this stage, we are laying the foundation for sustained growth while insulating the business from land price volatility and cyclical supply constraints.”

Execution & Capital Deployment

The upcoming portfolio is largely oriented towards large-format and mixed-use developments, which typically involve longer development cycles of 3–5 years. Consequently, the financial impact of this expanded pipeline is expected to crystallize progressively over the coming years.

To support execution, the Company estimates total project investments to exceed INR 2,000 crore, to be deployed in a phased manner aligned with the project timelines and development milestones.

Future Growth Runway

In addition, Kesar India is currently in advanced stages of evaluating further opportunities with an estimated potential GDV of over INR 4,000 crore, reinforcing the expansion momentum. These opportunities are subject to due diligence, regulatory approvals, and execution of definitive agreements and reflect the Company’s continued focus on strengthening its future growth runway.

BMGE 2025: Bosch Highlights Breakthroughs in Safety, Software, and Sustainable Mobility

Business Wire India — Mon, 20 Jan 2025 01:37:39 +0530

New Delhi, India: Bosch Limited, a leading global supplier of technology and services showcases its innovative advancements towards the future of automotive sector at the Bharat Mobility Global Expo (BMGE) 2025, held from January 17–22. With a focus on state-of-the-art safety systems, advanced software solutions, and electrification breakthroughs, Bosch is presenting transformative solutions at two locations, aimed at shaping a safe, sustainable, and exciting tomorrow.

“The future of mobility will be defined by a decisive push towards electrification, more climate-friendly fuels, and seamless integration of AI-driven solutions. Bosch is spearheading this transformation, by being ready for a sustainable and digitally empowered future. Bharat Mobility Global Expo provides us with a platform to showcase our portfolio, foster collaboration and demonstrate our efforts in enabling technologies that will redefine how we move for years to come,” said Guruprasad Mudlapur, President of the Bosch Group in India and Managing Director, Bosch Limited.

Visitors to the Bosch pavilion at Bharat Mandapam (Pragati Maidan) can explore a range of cutting-edge solutions including:

Hydrogen Demonstrator Truck: Showcasing Bosch’s advancements in hydrogen technology, this experiential vehicle represents the company’s efforts to accelerate zero-emission and sustainability-oriented mobility. In India, hydrogen engines present a promising alternative to diesel for long- haul trucks. Bosch has invested approximately $2 billion in hydrogen technology globally, reinforcing its leadership in this domain.

Vehicle Motion: Discover Bosch’s advancements in automotive safety technologies through features like Intelligent Turn Assist and Auto Vehicle Hold. While the former enhances maneuverability and safety during sharp turns or off-road conditions ensuring smoother, controlled turns, Auto Vehicle Hold adds convenience and safety during stop-and-go traffic conditions.

Software & Services: Bosch is a pioneer in software-defined vehicle (SDV) innovation, driving the evolution of mobility. Experience its SDV expertise at the Expo via exciting live demonstrations of generative AI, advanced E/E architecture, cloud-native tools, and seamless on-device and cloud integration, integrating the user and the ecosystem as core elements of a personalized automotive experience.

Advanced Rider Assistance Systems (ARAS): Get to know about Bosch’s exciting, advanced rider assistance systems comprising of ACC (adaptive cruise control), forward collision warning and blind spot detection. Leveraging Bosch’s radar sensor, brake system, engine management system and HMI (human machine interface), the system boosts rider awareness of their surroundings, contributing to increased comfort and rider reassurance.

At the Auto Components Show 2025 in Dwarka, Bosch is emphasizing on its hardware expertise by showcasing advanced EV components, diverse fuel injection equipment, sensors for various powertrains, braking systems, ADAS solutions and more coupled with an immersive experience around Bosch’s manufacturing solutions This exemplifies Bosch’s capability to seamlessly integrate hardware and software, delivering end-to-end capabilities to cater to an ever-evolving mobility landscape.

“At Bharat Mobility Global Expo, we present a range of advanced solutions that reaffirm our commitment to shaping India’s mobility future. From alternate powertrains to innovative safety solutions, software led capabilities, logistics and more, Bosch’s offerings are leading the way in creating a safer, sustainable, and digitally connected mobility ecosystem. As the sector evolves, our dedication to providing customers with solutions tailored to their success remains unchanged,” said Sandeep Nelamangala, Joint Managing Director, Bosch Limited and President, Bosch Mobility India.

About Bosch in India

In India, Bosch is a leading supplier of technology and services in the areas of Mobility Solutions, Industrial Technology, Consumer Goods, and Energy and Building Technology. Additionally, Bosch has in India the largest development center outside Germany, for end-to- end engineering and technology solutions. The Bosch Group operates in India through twelve companies: Bosch Limited – the flagship company of the Bosch Group in India – Bosch Chassis Systems India Private Limited, Bosch Rexroth (India) Private Limited, Bosch Global Software Technologies, Bosch Automotive Electronics India Private Limited, BSH Home Appliances Private Limited, ETAS Automotive India Private Limited, Robert Bosch Automotive Steering Private Limited, Bosch Mobility Platform and Solutions India Private Limited, Newtech Filter India Private Limited, Precision Seals Manufacturing Ltd and Mivin Engg.Technologies Private Limited. In India, Bosch set-up its manufacturing operation in 1951, which has grown over the years to include 17 manufacturing sites, and seven development and application centers. The Bosch Group in India employs over 39,769 associates and generated consolidated sales of about Rs. 37,912 crores (4.2 billion euros) in fiscal year 2023-24 of which Rs. 34,816 crores (3.8 billion euros) are from consolidated sales to third parties. Bosch Limited is the flagship company of the Bosch Group. It earned revenue of over Rs. 16,727 crores (1.86 billion euros) in fiscal year 2023-24.

Additional information can be accessed at www.bosch.in

The Bosch Group is a leading global supplier of technology and services. It employs roughly 429,000 associates worldwide (as of December 31, 2023). The company generated sales of 91.6 billion euros in 2023. Its operations are divided into four business sectors: Mobility, Industrial Technology, Consumer Goods, and Energy and Building Technology. With its business activities, the company aims to use technology to help shape universal trends such as automation, electrification, digitalization, connectivity, and an orientation to sustainability. In this context, Bosch’s broad diversification across regions and industries strengthens its innovativeness and robustness. Bosch uses its proven expertise in sensor technology, software, and services to offer customers cross-domain solutions from a single source. It also applies its expertise in connectivity and artificial intelligence in order to develop and manufacture user-friendly, sustainable products. With technology that is “Invented for life,” Bosch wants to help improve quality of life and conserve natural resources. The Bosch Group comprises Robert Bosch GmbH and its roughly 470 subsidiary and regional companies in over 60 countries. Including sales and service partners, Bosch’s global manufacturing, engineering, and sales network covers nearly every country in the world. Bosch’s innovative strength is key to the company’s further development. At 136 locations across the globe, Bosch employs some 90,000 associates in research and development, of which nearly 48,000 are software engineers.

The company was set up in Stuttgart in 1886 by Robert Bosch (1861–1942) as “Workshop for Precision Mechanics and Electrical Engineering.” The special ownership structure of Robert Bosch GmbH guarantees the entrepreneurial freedom of the Bosch Group, making it possible for the company to plan over the long term and to undertake significant upfront investments in the safeguarding of its future. Ninety-four percent of the share capital of Robert Bosch GmbH is held by Robert Bosch Stiftung GmbH, a charitable foundation. The remaining shares are held by Robert Bosch GmbH and by a corporation owned by the Bosch family. The maįority of voting rights are held by Robert Bosch Industrietreuhand KG. It is entrusted with the task of safeguarding the company’s long-term existence and in particular its financial independence – in line with the mission handed down in the will of the company’s founder, Robert Bosch.

Additional information is available online at www.bosch.com, www.iot.bosch.com, www.bosch- press.com.

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